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Abstract

FORMULATION AND EVALUATION OF INSITU GEL CONTAINING PEFLOXACIN MESYLATE

Pentewar Ram Shankarrao*, Mali Supriya, Prof. R.V.Sugave, Dr. Bhushan Patil, Kore Priyanka

ABSTRACT

The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid precorneal elimination of the drug may be overcome by use of in–situ gel forming system that are instilled as a drops into the eye and it undergoes a sol-gel transition in the cul-de-sac. The present work describes the formulation and evaluation of an ophthalmic delivery system of an antibacterial agent, Pefloxacin, using xanthan gum as a gelling agent in combination with HPMC K15 as viscosity enhancing agent which is used in the treatment of eye infection such as, bacterial conjunctivitis, corneal ulceration and blepharitis, based on the concepts of pH-triggered In -situ gelation, thermo reversible gelation and Ion activated system. In situ gelling system of Pefloxacin Mesylate provides sustained release of drug based on polymeric carriers that undergo sol-to-gel transition upon change in temperature & PH. The formulations were evaluated for clarity, pH measurement, gelling capacity, drug content estimation, rheological study, in vitro release study. The optimized formulation F6 was stable and provided sustained release up to 92% at the end of 8th hour and it is a viable alternative to conventional eye drops. The developed system is thus a viable alternative to conventional eye drops.

Keywords: In situ gel, Gelling capacity, Rheological evaluation, In vitro diffusion study.


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