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K. Navaneetha*, A. Navya, B. Venkateswara Reddy, T. Saritha and N. Jabili


The aim of the present work is to prepare and evaluate the sustained release nanoparticles of Linagliptin an anti diabetic in order to improve its therapeutic effect and reducing dosing frequency and its dose related side effects. Linagliptin containing Polycaprolactone and Polyvinyl Alcohol (PVA) nanoparticles were prepared by solvent evaporation method. The result showed that this method is reproducible and led to the efficient entrapment. Formulation had spherical particles in the particle range from 100 - 1500nm. Some process variables like effect of PVA concentration, Polycaprolactone concentration were also evaluated with respect to drug content and encapsulation efficiency. The maximum encapsulation efficiency is 89 ± 0.61%. The sustained release behaviour of nanoparticles were evaluated in phosphate buffer saline and results revealed that Linagliptin loaded nanoparticles are most suitable mode of delivery of drug for promising therapeutic action.

Keywords: Linagliptin; Polycaprolctone; Polyvinyl Alcohol; solvent evaporation method.

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