WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

IN VITRO ANTI-SKIN AGEING BENEFITS OF CLERODENDRUM PANICULATUM LEAF EXTRACTS.

Dilmel Krishnan R.*, Vijayakumar M., Sandeep Varma R., Ilavarasu A. and Dhanabal S. P.

ABSTRACT

Clerodendrum paniculatum (Family: Lamiaceae) or Hanuman kireetam is a well-known ayurvedic plant but less explored in India. The objective of the present study was to check the anti-skin ageing benefits of methanol and water extracts of C. paniculatum leaves In vitro. The Collagen-I, Elastin and Hyaluronidase assays was performed on Human dermal fibroblast cells (HDF).The antioxidant potential of C. paniculatum leaf water (CPW) and methanol extracts (CPM) was checked by reducing power assay. The CPM and CPW extract was non-toxic to the cells with CTC50 above 200μg/mL. CPM and CPW showed good anti-oxidant activity comparable to Ascorbic acid at 200μg/mL. The Collagen and Elastin content was increased in the extract treated cells as compared to control. The Hyaluronidase inhibition confirmed increased hydration in cells for CPM and CPW respectively. HPLC chromatogram profile of CPM and CPW was developed using Acetonitrile: water as mobile phase in the ratio of 70:30. This study confirmed the presence of flavonoids, Quercetin and Rutin, as biomarkers in CPM extracts and CPW. Both water and methanol extract showed good skin anti-ageing activity in HDF .The study overall substantiates our objective of anti-skin ageing activity of CPW and CPM leaf extracts, and can be explored as potential ingredient in skin care formulations.

Keywords: Clerodendrum paniculatum, Quercetin, Rutin, Anti-ageing.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More