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Abstract

PREVALENCE OF METABOLIC SYNDROME IN PATIENTS WITH RHEUMATOID ARTHRITIS AND ITS CORRELATION WITH DISEASE ACTIVITY-A CASE CONTROL STUDY

Jayapal T*, Athul U., Rajasekharan C. and AKhil Krishna

ABSTRACT

Background: Accelerated atherosclerosis due to chronic inflammation is the proposed reason for the increased cardiovascular disease related events in rheumatoid arthritis patients. An increased prevalence of metabolic syndrome is also studied worldwide. Objectives: To study the prevalence of metabolic syndrome in patients with rheumatoid arthritis and its correlation with disease activity. Methodology: A case controlled study was conducted in 80 patients with rheumatoid arthritis and 100 controls without rheumatoid arthritis were studied. Details were obtained in structured format. Prevalence of metabolic syndrome defined by NCEP ATP III criteria among cases and control group was estimated. Disease activity was measured using DAS 28 score based on ESR. Results: Statistically significant increased prevalence of diabetes mellitus was noticed in RA group (58.8%) when compared to the control group (33%). Among RA group 50% were overweight and 16.3% were obese. Among control group 32% were overweight and 11% were obese. An abnormal BMI was observed in 66.3% of cases and 43% controls which was statistically significant. {Odds ratio 2.602. 95% CI for OR= 1.415-4.787}. Metabolic syndrome was observed in 42.5% of patients in RA group when compared to 18% in the control group. {Odds ratio 3.367. 95% CI for OR= 1.713-6.619. The mean DAS score in RA patients with and without metabolic syndrome was 5.4656 and 4.6598 respectively. Conclusion: The prevalence of abnormal body mass index, type 2 diabetes mellitus and metabolic syndrome are significantly high patients with rheumatoid arthritis. Disease activity is high in patients with rheumatoid arthritis and metabolic syndrome when compared to patients with rheumatoid arthritis without metabolic syndrome.

Keywords: Rheumatoid arthritis, metabolic syndrome, Disease activity, DAS-28 score, body mass index, tender joint count, swollen joint count.


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