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Abstract

FORMULATION AND EVALUATION OF ORAL FAST DISSOLVING FILM OF GLIPIZIDE

Thonte S.S., Pentewar R.S., Bhusnure O.G.*, Gholve S.B., Gaikwad V.M., Pujdekar
Akash A.

ABSTRACT

Aim of the present study was to develop the Fast Dissolving Oral Films of Glipizide. It is second-generation sulfonylurea that can acutely lower the blood glucose level. Fast dissolving oral films deliver drug directly in the vascular system and bypasses the hepatic first pass metabolism so dose of the drug may also reduce significantly. Fast dissolving films were prepared using solvent casting method, hydrophilic polymers (HPMC K-15, HPMC E-15, HPMC K- 100) were selected as film forming agents and PEG-400 was used as plasticizer to give flexibility to the films. In FT-IR study no interaction was observed between drug and the excipients. Three blank films were selected for the incorporation of drug. After characterization the drug loaded films and studying their disintegration time & in-vitro drug release studies, among the formulations [F1 - F10] F3, F4, F6, F7 & F9 was selected the best formulation as its disintegration and dissolution time was less and it releases drug to a greater extent from 93% to more than 100% in ten minutes. Formulation F9 was selected best formulation as its disintegration and dissolution time was less and it released drug to a greater extent compared to other formulations. Therefore fast dissolving oral films can play an important role in oral drug delivery.Drug loaded films with both the polymers were stable under 40°C/75% RH conditions.

Keywords: Orally disintegrating film, Glipizide, HPMC, Solvent casting method, Drug release.


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