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Abstract

FORMULATION AND IN VITRO EVALUATION OF CONTROLLED RELEASE MEBEVERINE HYDROCHLORIDE MICROSPHERES

G.Velrajan*, Dr.R.Suthakaran and V.Balasubramaniam

ABSTRACT

Microspheres of mebeverine hydrochloride, which treats irritable bowel syndrome. Mebeverine hydrochloride ishighly water soluble drug, having poor oral bioavailability of drug. Mebeverine hydrochloride is known to suffer from first pass effect. It is an attempt to improve oral bioavailability, reduce the frequency of drug administration, and possibility to restrict its absorption only to the colon. In this study, microspheres of mebeverine hydrochloride was prepared by solvent evaporation techniques using Eudragit FS 30D, and Ethylcellulose as polymers and yield, particle size, encapsulation efficiencies and in vitro release of the prepared microspheres were evaluated. The results showed that percentage yield, encapsulation efficiencies and particle size were influenced mainly by polymer concentration, type of polymer and stirring speed. From the results of the in vitro study shows that the desired release rate is achieved byFEC 4 and FER 11 formulations are releasing the drug up to 12 hrs. DSC results showing there is no interaction between drug and polymers. SEM results of optimized microspheres showing discrete, spherical microspheres.

Keywords: Mebeverine hydrochloride, ethylcellulose N 50, eudragit FS 30 D, Solvent evapouration technique.


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