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Abstract

LIQUISOLID TECHNIQUE: AN OVERVIEW ON ENHANCED SOLUBILITY AND BIOAVAILABILITY

Abhilasha* and Bhagchand

ABSTRACT

One of the most innovative dosage form used for enhancing dissolution rate and improving in vivo bioavailability of poorly soluble drugs is “liquisolid technology” Liquisolid systems essentially relate to formulations prepared by converting a liquid drug or a drug in liquid state (solutions, suspensions, or emulsions) into dry, non-adherent, free-flowing, and readily compressible powder mixtures by blending a liquid dispersion onto specific powder carriers and coating materials. Hence, liquisolid technique is also known as “powder solution technology. As these days there are many drugs in the market with poor solubility which results in poor dissolution and bioavailability, so solubility is becoming rate limiting factor in the development of new drugs. To succeed in dealing with this problem of solubility, there are many techniques but liquisolid technique is most promising technique which is discussed in this article. Drug, nonvolatile solvent, carrier material, coating material, and disintegrants are the main components of liquisolid technique. In liquisolid technique carrier and coating material is mixed into the non-volatile solvent and then disintegrants is added and for tablet formulation final material is compressed. Therefore, the liquisolid technology allows the conversion of liquid systems into solid drug delivery systems. The main objective of this article, to explain about the liquisolid technique like method, classification, optimization, advantages, disadvantages, applications, pre-formulation studies, characterisation, formulation of tablet, postcompression studies, evaluation.

Keywords: Liquisolid, bioavailability, dissolution, carrier material, emulsion, coating material.


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