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Abstract

PHYTOSOMES AN EMERGING TECHNOLOGY FOR HERBAL DRUG DELIVERY: AN APPROACH TO HEPATOPROTECTION

Chandraprakash Dwivedi*, Surbhi Kesharwani , Sandip Prasad Tiwari, Trilochan Satapathy, Amit Roy

ABSTRACT

Phytoconstituents, despite having excellent bioactivity in vitro, demonstrate less or no in vivo actions due to their poor lipid solubility or improper molecular size or both, resulting in poor absorption and poor bioavailability. Lipid solubility and molecular size are the major limiting factors for molecules to pass the biological membrane and to be absorbed systematically following oral or topical administration. Some phytoconstituents are destroyed in the gastric environment when taken orally. The term “phyto” means plant, while “some” means celllike. Therefore, phytosome is a “phytophospholipid complex” resembling a small cell. Phytosomes are produced by a patented process whereby standardized plant extracts or their constituents are bound to phospholipids, mainly phosphatidylcholine, producing a lipid-compatible molecular complex. Phytosomes exhibit a better pharmacokinetic and pharmacodynamic profile than conventional herbal extracts. The phytosome technology markedly enhances the bioavailability of phytomedicine and has effectively enhanced the bioavailability of many popular herbal extracts, including milk thistle, ginkgo biloba, grape seed, green tea, hawthorn, ginseng etc., and can be developed for various therapeutic uses or dietary supplements. .the focus of this review is to elucidate the concept of hepatotoxicity, including its causes, pathogenesis and prevention. The article also reviews the scope of herbal plants as well as novel delivery systems like phytosomes for the treatment of hepatotoxicity and liver related disorders. It has a lot of potential in the field of medicine, pharmaceuticals and cosmetics.

Keywords: Drug delivery, phosphatidylcholine, phytoconstituents, hepatotoxicity, Herbal.


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