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Abstract

A CROOS SECTIONAL STUDY IN NORTH EASTERN UTTAR PRADESH POPULATION FOR THE ESTIMATION OF HDL, TRIGLYCERIDES LEVELS IN RECENTLY DIAGNOSED PATIENTS WITH DIABETES MELLITUS TYPE 2 TAKING METFORMIN ALONE, METFORMIN WITH ADD ON SITAGLIPTIN AND SITAGLIPTIN ALONE

Neerjesh*, Vipender Singh Chopra, Raj Kishore Singh, Rakesh Chandra Verma, Praduman Mall and Gyanendra Kumar Bind

ABSTRACT

Objectives: To evaluate the role of Metformin, Sitagliptin & combination of both drugs in Body weight, HDL-C & Triglyceride levels in recently diagnosed patients of type 2 Diabetes mellitus. Methods: This cross-sectional study include analysis of total 75 patients were divided in 3 groups. Metformin group (2000mgs), Sitagliptin group (100 mgs), Combination of both Metformin & Sitagliptin group (Metformin 1000 mg+ Sitagliptin 50 mg). Their body weight (BMI) & Laboratory investigations regarding HDL & Triglycerides were carried out and findings were noted in each followups. Results: After 24 week onwards there were statistically significant reduction in BMI in each group but in the 3rd group (Combination group) patients the reduction in BMI was Most highly significant (p< 0.001). On other hand HDL level was raised significantly (p<0.01) in all the three groups but in the Sitagliptin and combined group it was most highly significant (p<0.001) observed from 24 week onwards, whereas in Triglyceride levels, Metformin and Sitagliptin, both group of patients showed significant (p<0.01) reduction. Metformin group showed significant (p<0.01) reduction earlier at 12 week and Sitagliptin showed significant reduction (p<0.01) later at 36 week. In the combined group it was insignificantly (p>0.05) fluctuating. Conclusions: In conclusion, significant differences was found in effects of Sitagliptin treatment on body weight (BMI) & HDL, Triglycerides level in patients recently diagnosed with type 2 Diabetes mellitus.

Keywords: Type 2 diabetes mellitus, Body weight, HDL-C, Triglycerides, Metformin, Sitagliptin.


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