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Abstract

DEVELOPMENT AND EVALUATION OF MUCOADHESIVE BUCCAL PATCH

Shrutika Zile* , Vaishali Wasnik*, Shilpa Gawande, Bharti Bakde, Madhuri Channawar

ABSTRACT

The present investigation involves formulation and evaluation of buccal patch of Valsartan, an antihypertensive drug to bypass the first pass metabolism. The buccal patch of Valsartan was prepared by solvent casting technique. Nine formulation were prepared with varying concentrations of bioadhesive polymers like Hydroxy propyl methyl cellulose K-100M and Sodium Alginate. Solvent ethanol was used with PEG-200 as plasticizer and Aspartame as sweetening agent. Drug-polymer interaction was investigated using FTIR. The prepared patches were evaluated for thickness, Surface pH, drug content uniformity, Ex vivo Mucoadhesive strength, % swelling index, folding endurance and in vitro drug release, Determination of Residence Time, Ex Vivo Permeation Study which produced satisfactory results with low standard deviation. After evaluation of all parameter, on the basis of results obtained batch F8 was found to be a optimize batch. This batch shows 97.15% Controlled Drug Release after 8 hrs and best fitted in Higuchi model for drug release kinetic.

Keywords: Mucoadhesive, Valsartan, Drug delivery, Controlled Drug Release.


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