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Abstract

FORMULATION, DEVELOPEMNT AND EVALUATION OF ZIPRASIDONE HYDROCHLORIDE CAPSULES BY DRY GRANULATION METHOD

Sangita B. Laware*, Deepak G. Wagh, Dr. Parag Kulkarni and Dr. Sadhana R. Shahi

ABSTRACT

The oral route is considered as the most promising route of drug delivery. Effective oral drug delivery may depend upon the factors such as gastric emptying process, gastrointestinal transit time of dosage form, drug release from the dosage form and site of absorption of drugs. Most of the oral dosage forms possess several physiological limitations such as variable gastrointestinal transit.[1] Variable gastric emptying gives non-uniform absorption profiles, incomplete drug release and shorter residence time of the dosage form in the required site. This leads to incomplete absorption of drugs having absorption window especially in the upper part of the small intestine, as once the drug passes down the absorption site, the remaining quantity goes unabsorbed.[2] The gastric emptying of dosage forms in humans is affected by several factors because of which wide inter- and intra-subject variations are observed. Since many drugs are well absorbed in the upper part of the gastrointestinal tract, such high variability may lead to non-uniform absorption and makes the bioavailability unpredictable. Hence a beneficial delivery system would be one which possesses the ability to control and prolong the gastric emptying time and can deliver drugs in higher concentrations to the absorption site (i.e. upper part of the small intestine). Floating systems are one of the important categories of drug delivery systems with gastric retentive behaviour.[3] Capsules are solid dosage forms in which the drug is enclosed within either a hard or soft soluble container or ‘shell.’ The shells are usually formed from gelatin; however, they also may be made from starch or other suitable substances. Capsule is the most versatile of all dosage forms. Capsules are solid dosage forms in which one or more medicinal and inert ingredients are enclosed in a small shell or container usually made of gelatin. The medication may be a powder, a liquid or a semisolid mass. Capsules are usually intended to be administered orally by swallowing them whole. Occasionally, capsules may be administered rectally or vaginally.[4]

Keywords: Dry granulation, direct compression, Roller compactor.


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