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Abstract

ULTRASOUND-ASSISTED EFFICIENT SYNTHESIS OF NOVEL THIAZOLIDINONE DERIVATIVES AS ANTICANCER AGENTS

Priyanka Gaikwad*, Anna Pratima Nikalije, Ramchandra N. Chilkawar, Pravinkumar Gutte and Jadishkumar Kelappan

ABSTRACT

A series of N-(2-substituted phenyl)- 4-oxothiazolidine-3- carbonothioyl benzamide derivatives (PG1-PG10) were designed and synthesized using Ultrasonic processor as an eco-friendly synthetic route, keeping in view the structural requirement of pharmacophore and evaluated for anticancer activity. N-carbamothioylbenzamide was prepared and thiazolidinone moiety was developed on it by cyclization of intermediate N-(benzylidenecarbamotioyl)-benzamide with thioglycolic acid in N,N- dimethyl formamide as solvent in presence of catalytic amount of zinc chloride, so as to get the novel final derivatives. Out of the 10 derivatives, compound number PG1,PG2 and PG5 were found to have potential activity against MCF-7 cell line whereas compound PG7 exhibited potential activity against HeLa cell line. As the synthesized derivatives showed good anti breast cancer and anti cervical cancer activity, these compounds can be further studied and optimized to help in development of anticancer drugs.

Keywords: A series N-carbamothioylbenzamide HeLa anti cervical drugs.


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