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Abstract

COMPARATIVE STUDY OF ANTI-INFLAMMATORY ACTIVITY OF WITHANIA SOMNIFERA WITH ASPIRIN IN EXPERIMENTAL ANIMALS (ALBINO RATS)

Dr. Kiran R. Giri, *Dr. Kamlesh M. Palandurkar and Dr. Reena R. Giri

ABSTRACT

The roots of Withania somnifera consist primarily of compounds
known as withanolides A & D, which are believed to account for its
extraordinary medicinal properties. Objective of the study is to
compare the anti-inflammatory effect of Withania somnifera &
NSAIDs (Aspirin). Acute inflammation was produced by sub-plantar
injection of 0.1 ml of 1% freshly prepared solution. The groups
consisted of complete Freund’s adjuvant (CFA)- 0.1ml injected rats
challenged with doses of the test drug and standard drug administered
orally 2 h before induction of arthritis. In our study we used 100mg/kg
Aspirin as a standard drug for evaluation of anti-inflammatory activity.
In present acute study, % inhibition of paw oedema was found to be
63.64% with aspirin as compare to 61.36% with Withania somnifera at
the end 3hrs.

Keywords: Withania somnifera, Anti-inflammatory activity, Aspirin.


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