WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

FORMULATION OF NOVEL TRANSFERSOMAL LOADED DRUG DELIVERY SYSTEM OF ACECLOFENAC FOR TOPICAL APPLICATION

Rasvita Gawas*, Clyte Fernandes and Rajashree Gude

ABSTRACT

To avoid the gastro intestinal side effects of the drug on chronic oral administration, to provide faster action, transdermal formulation of Aceclofenac entrapped in transfersomes was formulated and evaluated. The aim of the present study involves formulation and evaluation of transfersomes of Aceclofenac by thin film hydration technique to improve the solubility and permeability of the drug. Transferomes were prepared using phosphatidylcholine and three different surfactants (Span 20, Span 60 and Span 80) as bilayer forming components. Formulations were evaluated for different parameters like; physicochemical properties (optical microscopy, particle size distribution, zeta potential measurement, SEM), % entrapment efficiency, in vitro release and stability studies. The % entrapment efficiency of the formulations was found to be in the range of 52.96 % to 67.25 %. in vitro release studies constant release of drug for the period of 8 hrs and maximum release of drug was shown by formulation F2 (83.6%). The optimized transferomal dispersion was incorporated into gel base using Carbopol 934P and test results obtained were acceptable and transfersomes were found to be stable in gel base.

Keywords: Transfersome, Phosphatidylcholine, Span, bilayer, vesicles


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More