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Abstract

POTENT ANTIDIABETIC ACTIVITY OF AQUEOUS EXTRACT OF BROWN SEAWEED PADINA BOERGESENII IN STREPTOZOTOCININDUCED DIABETIC RATS

Senthilkumar P.*, Ranjith Santhosh Kumar D. S., Surendral L., Sudahar B., Nazir Hazza Abdul Karim Taha, Harshini J. and Sathya Priya N.

ABSTRACT

Identification of new drugs from marine has major focus of researchers. In the present study, the effect of aqueous extract of brown algae Padina boergesenii in streptozotocin (STZ) induced diabetic rats. Diabetes mellitus was induced by a single intraperitoneal injection of STZ (60 mg/kg bw). Oral administration of the effective dose of P. boergesenii to the diabetic rats for 20 days showed abridged effects on protein, hemoglobin and glycosylated hemoglobin levels. Significant difference was observed serum urea, uric acid and creatinine levels in diabetic rats after P. boergesenii extract treatment (p<0.005). The extract of P. boergesenii significantly increased the activities of protein, hemoglobin in liver and kidney of control and experimental rats. The effect of urea, uric acid and creatinine was more pronounced in serum, liver and kidney lipid profile treatment with the P. boergesenii extract. The present study clearly indicated significant antidiabetic effect with the P. boergesenii shows to have a potential value for the development of an effective phytomedicine for diabetes and lends support for its traditional usage.

Keywords: Seaweed, aqueous extract, Padina boergesenii, antidiabetic activity, Streptozotocin.


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