WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

PRELIMINARY SCREENING OF PSYCHOPHARMACOLOGICAL EFFECTS AND TOXICITY TESTING OF TENSNIL SYRUP IN SWISS ALBINO MICE

Shah Krishna M.*, Mody Vandana and Goswami Sunita S.

ABSTRACT

Background: Tensnil syrup is a polyherbal formulation (PHF) containing ingredients such as, extracts of garmarogor, devdaru, shankhavali, pitapapapdo, brahmi, jatamansi, nagarmoth, kadu, tagar, himaj, draksha, ashwagandha. Aims: This formulation was evaluated for its safety by repeated dose sub-acute oral toxicity study in swiss albino mice, dose range finding study and also for its acute antidepressant and anxiolytic effects on central nervous system (CNS) using behavioural models. Materials and Methods: The PHF was administered orally at a therapeutic dose range (100 - 800 mg/kg/day), for 28 days. All animals were monitored daily for their health status and signs of abnormalities. The body weight and food intake were measured once weekly. At the end of the experimental period, various haematological and biochemical parameters were estimated. For acute study, forced swim test (FST), tail suspension test (TST), elevated plus maze (EPM) and photoactometer tests were performed at doses of 400 and 800 mg/kg. Fluoxetine (20 mg/kg, p.o.) was used as standard. Results: Long term use of PHF did not show any remarkable change in physical, haematological and biochemical parameters. Further, single dose treatment of PHF for 7 days at the dose of 400 and 800 mg/kg, showed significant antidepressant and anxiolytic activity as evident from significant reduction of immobility time in FST and TST along with increased number of cut – offs and time spent in close arm in EPM. Conclusions: The study established the safety and efficacy of PHF in mice. Also this acute study reveals antidepressant and anxiolytic activity of Tensnil syrup.

Keywords: Formulation, Repeated Dose Oral Toxicity, Neurophyscological Effects.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More