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Abstract

EVALUATION OF RESISTANCE TO CARBAPENEM BY DISC DIFFUSION METHOD AND SUSCEPTIBILITY TO POLYMYXIN-B USING E-STRIP IN ENTEROBACTERIACEAE

Tabrez Ahmad, Harelimana Jean Marie Vianney, Mucumbitsi Joseph, Abdulhamid Tahir Hamid*, Shafiu Muhammad Tahir and Nawiyyu Musa

ABSTRACT

Although this family of enterobacteriaceae includes more than 70 genera, the health-care associate, most commonly found in this current study were Escherichia coli, Klebsiella species, Enterobacter, Salmonella, Enterobacter and Proteus species. Isolates were inoculated in Muller Hinton Agar, antibiotic and polymyxin-B E-strip were applied and incubated at 37 degrees Celsius the inhibition zone size were read after overnight of incubation and compared to antimicrobial chart of NCCLs. The present study showed that in 119 isolates samples 10(8%) of them showed Expended Spectrum Beta lactamase production which cause resistance to 3rd generation cepharosporin antibiotics, and all 10 isolates were from Escherichia. Coli strain, none of Klebsiella, Proteus, Citrobacter, Salmonella or Enterobacter species showed ESBLs production. The present study also showed that in 119 isolated Enterobacteriaceae samples 25(21%) of them showed resistance to carbapenem antibiotics, within 25 carbapenem resistant Enterobacteriaceae isolates, 9(36%) were E. coli whereas 16(64%) were Klebsiella. The present study also showed that all carbapebem resistant Enterobacteriaceae isolates were susceptible to polymyxin-B antibiotic. Given the fact that the prevalence of CRE was increasing during the past decades, it is urgent for us to establish regional surveillance worldwide, carry out more effective antibiotic stewardship and infection control measures to prevent further spread of carbapenem resistance in Enterobacteriaceae. Health departments should be well positioned to play a leading role in prevention, efforts by assisting with surveillance, situational awareness, and coordinating prevention efforts.

Keywords: Evaluation, Resistance, Carbapenem, Disc Diffusion Method, Susceptibility, Polymyxin-B, E-Strip, Enterobactericiae.


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