WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

FORMULATION AND INVITRO EVALUATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM

Azeez Mohammad*, Potlapally Laxmi, S. Swathi and G. Shirisha

ABSTRACT

The present Researchwork was aimed at enhancing the solubility of Candesartan cilexetil by formulating SEDDS (self-emulsifying drug delivery system) evaluating its in vitro potential. The solubility of Candesartan cilexetil was determined in various vehicles. Various combinations of oils (arachis oil, Sunflower oil, coconut oil and soybean oil), surfactant (Cremophor Rh 40), and co-surfactant (polyethylene glycol 400) were used to formulate SEDDS. Pseudo ternary phase diagram was used to evaluate the effective emulsification area. SEDDS formulations were tested for emulsifying properties and the resultant emulsions were evaluated for clarity, precipitation, particle size distribution and drug release studies. Optimization of the formula and screening was done based on characteristics of resultant emulsions. The optimized formulation composed of soybean oil (45%), Cremophor Rh 40 (50%), and polyethylene glycol 400 (05%) and showed complete drug release in 60 minutes which was far better than that of plain drug.

Keywords: Candesartan cilexetil, SEDDS, pseudo ternary phase diagrams, angiotensinreceptor blocker, BCS class II drug.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More