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Abstract

BIOACTIVE METABOLITES FROM AN ENDOPHYTE OF THE MEDICINAL PLANT CENTAUREA STOEBE

Randa Abdou*

ABSTRACT

An endophytic fungus was isolated from the stems of the medicinal plant Centaurea stoebe. The ethyl acetate extract of the fungal isolate exhibits significant antifungal activity as well as potent cytotoxic and antiproliferative effects against HUVEC, K-562 and HeLa cancer cell lines. Activity-guided fractionation resulted in the isolation of the antifungal and phytotoxic metabolite hydroxymellein, an antimalarial diketopiperazine and the antibacterial natural product epicoccin A. Epicoccin A exhibits weak cytotoxicity and strong antiproliferative effects.

Keywords: Centaurea stoebe, diketopiperazine, hydroxymellein, endophytes


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