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Abstract

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF METFORMIN

* Subhendu S. Mishra1, Ashish Pathak1, Amit Dubey1, Dinesh Bajpai2, Niraj Upmanyu2

1Sapince Bioanalytical Research Laboratory, Bhopal, M.P, India.
2R.K.D.F College of Pharmacy, Bhopal, M.P, India.

ABSTRACT

In this investigation fast dissolving tablets of Metformin Hcl were prepared using different super disintegrants by direct compression method. Fast dissolving tablets prepared by direct compression and using super disintegrants like Croscarmellose sodium and crospovidone in different concentration and evaluated for the precompression parameters such as bulk density, compressibility, angle of repose etc. The prepared batches of tablets were evaluated for hardness, weight variation, friability, drug content, disintegration time and in-vitro dissolution profile and found satisfactory. Among all, the formulation F5 containing super disintegrant crospovidone was considered to be best formulation, which release up to 98.91% in 5 min.

Keywords: Metformin HCl; Mouth dissolving tablet; super disintegrants; Dissolution rate.


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