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Abstract

PROTECTIVE EFFICACY OF GLYCYRRHIZA GLABRA ON CCl4 INDUCED LIVER INJURY IN RABBITS

Tahani Y. Omar *

ABSTRACT

The present study was carried out to investigate the protective effects of Glycyrrhiza glabra L roots powder juice on some biochemical parameters in normal (non- CCl4-induced hepatic injury) and CCl4- induced hepatic injury rabbits. A dose of 2.0 g/kg body weight of aqueous extract of roots was orally administered daily to normal and CCl4-induced hepatic injury rabbits for 7 days. The levels of AST, ALT, ALP, creatinine and urea were significantly (P<0.05) increased in the serum of CCl4-induced hepatic injury rabbits as compared to the (non-CCl4-induced hepatic injury rabbits. In contrast, glucose concentration was significantly decreased in CCl4-induced hepatic injury rabbits, as compared to the non- CCl4-induced hepatic injury rabbits. Significant reduction in the hepatic enzymes levels AST, ALT, ALP, serum creatinine, serum urea and improvement of serum glucose was found in animals treated with the extract before CCl4- induced hepatic injury. The present study demonstrated that the G. glabra roots extract had a significant effect in liver functions in acute liver diseases when it was given in a single daily dose of 2.0 gm/kg rabbit body weight for seven days. Therefore the aqueous extract of G. glabra roots can be used for prevention and treatment of liver disorders.

Keywords: Glycyrrhiza glabra (Licorice); Carbon tetrachloride; Induced hepatic injury rabbits; Hepatic enzymes; Biochemical parameters.


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