WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

INVESTIGATION INTO THE ANTI-ULCER ACTIVITY OF THE METHANOL EXTRACT OF STEMONOCOLEUS MICRANTHUS HARMS, BARK (FAM: LEGUMINOSEAE)

Ezea, C.C*; C.T. Nnamdi-Okenwa, C.O. Ezugwu, F.C. Anowi,S.C. Ezea.

ABSTRACT

The objective of this study was to investigate the anti-ulcer activity of methanolic extract of Stemonocoleus micranthus Harms, Bark (Leguminoseae) in rats. Fresh dried barks of Stemonocoleus micranthus were extracted by cold maceration technique with methanol as the solvent and the yield was concentrated on a rotary evaporator. Anti-ulcer effects of the methanolic extract at 25, 50 and 100 mg/kg were evaluated in rats using indomethancin induced ulcer model. Phytochemical analysis and lethality tests (LD50) were carried out using standard methods. Results showed that the methanolic extract exhibited significant (P<0.05) and dose-dependent anti-ulcer activity in the model used. Percentage ulcer inhibitions of the methanolic extract at 25, 50 and 100 mg/kg for indomethacin induced ulcers were 30.80, 52.70 and 70.50 % respectively. Ulcer protections in the model used by the methanolic extract is dose – dependent and the ulcer inhibitory effect of the extract was comparable to cimetidine at 100 mg/kg. Oral LD50 value greater than 5000 mg/kg was obtained indicating the safety of the plant for consumption. Phytochemical analysis showed the presence of tannins, saponins, glycosides, carbohydrates, reducing sugars, proteins, terpenoids, steroids and flavonoids. Therefore, results of our study suggest that the methanolic extract of Stemonocoleus micranthus possesses anti-ulcer activity as claimed by its traditional use.

Keywords: Anti-ulcer activity, S. micranthus stem bark, phytochemical analysis.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More