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Abstract

ANALYTICAL METHODS FOR THE DETERMINATION OF LEFLUNOMIDE - A SHORT REVIEW

Shah Kruti V.*, Chauhan Sanjay P., Suhagia B. N.

ABSTRACT

Leflunomide is a pyrimidine synthesis inhibitor belonging to the (DMARD) class of drugs, used to treat the symptoms of rheumatoid arthritis. It also helps to reduce joint damage and improves physical functioning and to slow the progression of structural damage associated with the disease. The substance is sold under the brand name Arava® by Sanofi-Aventis. Arava® was approved by the U.S. Food and Drug Administration (FDA) and by many other countries (e.g., Canada, Europe) in 1998.A widespread review of the literature published in various pharmaceutical journals has been conducted and the instrumental analytical methods which are developed and used for determination ofLeflunomide have been reviewed. This review includes UV-Visible Spectroscopy, RP-HPLC-UV, LC-MS/MS, LC-ESI-MS/MS and UPLC-PDA. The applications of these methods for the determination of Leflunomide in pharmaceutical formulations and biological sample have also been discussed in this article.

Keywords: Leflunomide; Teriflunomide (A771726)


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