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Abstract

A NEW RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF ETODOLAC AND THIOCOLCHICOSIDE IN TABLET DOSAGE FORMS

K. Sujatha*, J.V.L.N. Seshagiri Rao

ABSTRACT

An accurate, precise and reproducible high performance liquid chromatographic method was developed for quantitative estimation of etodolac and thiocolchicoside simultaneously in tablet dosage forms. Separation of the drugs was achieved within 10 min on a Kromosil C18 (150 x 4.6 mm, 5) column by isocratic elution using a mixture of acetate buffer (pH 3.7) and methanol (20:80 v/v) as the mobile phase at a flow rate of 0.8 mL/min. The analytes in the eluate were monitored at 242 nm. Under the optimized conditions, the retention times obtained for etodolac and thiocolchicoside were 3.176 min and 2.285 min respectively. The linearity of quantification was observed in the concentration range of 100 – 600 μg/mL for etodolac and 1 – 6 μg/mL for thiocolchicoside. The performance of the method was validated according to ICH guidelines. The method was found to be suitable for accurate determination of these drugs in tablet dosage forms without any interference from normal excipients.

Keywords: Etodolac, Thiocolchicoside, Determination, HPLC, Isocratic


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