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Abstract

HEPATOPROTECTIVE ACTIVITY OF ARGEMONE MEXICANA LINN AGAINST TOXIC EFFECTS OF CARBON TETRACHLORIDE IN RATS

*Showket Hussain Bhat, Rajni Shrivastava, Mohd Yousuf Malla, Mohd Iqbal,Tahira Anjum, Abrar Hussain Mir, Manik Sharma

ABSTRACT

The aim of this study was to evaluate the hepatoprotective effects of ethyl acetate extract of Argemone mexicana Linn in carbon tetrachloride (CCl4)-treated rats. Animals were pretreated with the ethyl acetate extract (200 & 400 mg/kg body weight) for one week and then challenged with CCl4 (1ml/kg bw) in olive oil (1:1, v/v) on 7th day. Serum marker enzymes (ALP, AST, ALT and Total Bilirubin) were estimated in all the study groups. Alteration in the levels of biochemical markers of hepatic damage like AST, ALT, ALP and Total Bilirubin were tested in both CCl4 treated and extract treated groups. CCl4 has significantly (P<0.001) enhanced the AST, ALT and ALP levels in liver. Treatment of ethyl acetate extract of Argemone mexicana Linn (200 & 400 mg/kg) produced significant (P<0.001) hepatoprotective effects as evidenced by decreased serum enzyme activities, AST, ALT, ALP and serum Bilirubin and an almost normal histological architecture of the liver, in treated groups, compared to the controls. The experimental results indicate that, ethyl acetate extract has excellent hepatoprotective effect. A similar experimental result was also observed by histological parameters.

Keywords: Hepatoprotective, Carbon tetrachloride, Histology, Biochemical markers.


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