WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

TERATOLOGICAL AND BIOCHEMICAL EFFECTS OF A FORMULATION CONTAINING QUINALPHOS, AN ORGANOPHOSPHATE INSECTICIDE IN THE CHICK EMBRYO

Mathur, P. and Taparia, N.*, L.Shahani

ABSTRACT

Present study was designed to investigate the toxic effect of Quinalphos 25% EC Flash, an organophosphate insecticide on chick embryos. The fertilized BV 300 eggs were immersed in low (15mg/l), median (31mg/l) and high (62mg/l) concentrations of the toxicant for one hour on embryonic day (ED) 4 of egg incubation. The teratogenecity was observed on ED 7 of incubation. For studying the biochemical parameters, whole embryo was taken.Level of total proteins and RNA was found to decrease significantly at all the dose levels while DNA was found to increase in a dose dependent manner, with highly significant increase at 62mg/l. However, Glycogen content showed insignificant change. Teratological changes observed in the present study included reduction in the size of brain and eyeballs; incomplete development of eyes, beak and wing buds; edema, gastroschisis, hematomas and hemorrhages. In some groups, eyes and in others beak was totally absent. The fresh body weight also showed significant reduction with increasing dose levels.

Keywords: Biochemistry. Chick embryo. Quinalphos. Teratology


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More