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Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE BILAYER TABLETS OF METFORMIN HCL AND PIOGLITAZONE HCL

*Bhalala chirag1, Chauhan Sachin1, Balaraman R.1, Seth A. K.1, Shah Chainesh1, Dhamat Khushal1, Hitesh Gevariya2

1Department of Pharmacy, Sumandeep Vidyapeeth, Gujarat, India
2Faculty of Pharmacy, Dharmsinh Desai University, Gujarat, India.

ABSTRACT

The present study was to establish Bi-layer tablets of Metformin HCL and Pioglitazone HCL of which Metformin HCL as sustained release and Pioglitazone HCL as immediate release layer. Sustained layer were prepared by wet granulation method using HPMC K4 as polymer, immediate release layer were prepared by direct compression method using superdisintegrants such as crosscarmellose sodium. The tablets were evaluated for Bulk density, Tapped density, Compressibility index, Hausner ratio, Angle of repose. All the values were found within limit of standard. In vitro release studies were carried out by USP type 2 paddle apparatus. The result showed that polymer HPMC K4 in sustained layer can control the release of drug. The in vitro release profile of drug from sustained release layer could be expressed by higuchi’s equation as pilot show high linearity R2=0.9911and diffusion was the dominant mechanism of drug release. The formulation (F9) having immediate release layer produces immediate effect 94.53±0.30 within 45 minutes followed by sustained release effect (95.77±0.37) upto 8 hours. The present study concluded that Bilayer tablets of Pioglitazone HCL and Metformin HCL can be a better alternative to conventional dosage form for providing sustained drug delivery.

Keywords: Bilayer tablet, Pioglitazone HCL, Metformin HCL, Sustained Release, Higuchi equation.


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