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Abstract

DESIGN AND SYNTHESIS OF NOVEL HYDROXY – ANTHRAQUINONE DERIVATIVES AS ANTI-LESHMANIAL AGENTS

Ubbani Ramakrishna* Alle Swathi, Sujatha Banavath, R. Suthakaran, Yelugudhari Ramulu, Ragya Eslavath and Goli Venkateshwarlu

ABSTRACT

To synthesized the novel series of hydroxy anthraquinones derivatives using Friedel-Crafts acylation reaction and were identified as potential antileishmanial chemotype. Among the synthesized eight analogues, 2 analogues (7f & 7g) exhibited better antileishmanial chemotype. Among the synthesized 8 analogues, 2 analogues (7f & 7g) exhibited better antileishmanial activity against intracellular amastigotes form of Leishmania donovani. The compounds were also non-toxic towards Vero cells. Compounds 7a, 7b and 7h also have significant in vitro activity (IC50 values of <10 μM) against intracellular amastigotes form of Leishmania donovani. 13C NMR of compound and 1H NMR of compound-7b produce the various spectral data.

Keywords: Antileishmanial activity, 13C NMR and 1H NMR Spectra, characterization.


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