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Abstract

DISSOLUTION ENHANCEMENT OF POORLY SOLUBLE ACECLOFENAC BY COMPLEXATION WITH β-CYCLODEXTRIN

*Dhamat Khushal, Shah Nirmal, Chauhan Sachin, SethA. K., Chintan Aundhia1, Bhalala chirag 

Sumandeep Vidyapeeth, Piparia, Waghodiya, Vadodara. Gujarat, India

ABSTRACT

Aceclofenac is an effective analgesic and anti-inflammatory drug prescribed widely in recent years for various types of pain and inflammation. Aceclofenac is partially insoluble in water and aqueous fluid and as such it exhibits poor variable oral bioavailability. Aceclofenac needs enhancement of solubility and dissolution rate to improve its oral bioavailability and therapeutic efficacy. Among the various approaches to enhance the solubility and dissolution rate of poorly soluble drugs complexation with cyclodextrin is an effective and industrially accepted technique. In the present investigation, Complexation of aceclofenac with β-CD was carried out by using various techniques like physical mixture, kneading method, coprecipitate method& solvent evaporation method. From the various characterization studies like drug content, production yield & in vitro dissolution study, batch abc-6 by kneading method was selected as optimised batch. Optimised batch was also studied for FTIR.

Keywords: Aceclofenac, β-cyclodextrin, FTIR, Solid Dispersion.


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