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Abstract

ASSOCIATION BETWEEN BLOOD AND FOLLICULAR FLUID OF LEAD AND OTHER MINERALS CONCENTRATION WITH EMBRYO QUALITY IN WOMEN UNDERGOING ICSI

Ruqaya Bashar Al-Smak*, Nawal khairy Al-Ani and Muayyed Sarbit

ABSTRACT

Background: Environmental pollution plays an important role in
affecting the internal milieu of humans. The amount of trace elements
in the environment is generally low, but these chemicals can interfere
with physiological systems. Thus, the health and welfare of individuals
could be compromised by exposure to environmental levels of
pollutants. Trace elements, mainly the toxicones, can adversely affect
reproductive system and its functions, through either direct or indirect
effects on numerous organs and systems. Objective: To assess the
effect of Lead concentration in blood and follicular fluid and Zinc in
serum and Follicular fluid on oocyte, embryo quality and pregnancy
success in women undergoing ICSI. Material and Methods: This study
included 70 infertile women undergoing ICSI will be enrolled in assisted reproductive
technologies (ART) program to enter their ICSI Cycle in High Institute of Infertility
Diagnosis and Assisted Reproductive Technologies and in Kamal Al-Samarrai Hospital,
center of fertility and IVF (Baghdad/Iraq) during the period from August 2016 to the end of
February 2017. "Blood and follicular fluid lead" and "serum and follicular fluid Zinc ", were
assessed on the day of oocyte retrieval by using Atomic Absorption Spectrophotometer
(AAS). Results: There was no significant difference between pregnant and non-pregnant
groups undergoing ICSI cycle in Lead concentration on the day of oocytes retrieval in both
blood and follicular fluid (22.09 ± 0.29 and 23.45 ± 1.21 μg/dl) and (13.58 and 15.94 μg/dl) respectively. Also there was no significant difference between pregnant and non-pregnant groups undergoing ICSI cycle in Zinc concentration on the day of oocytes retrieval in both serum and follicular fluid (67.56 and 68.42 μg/dl) and (84.58 and 80.83 μg/dl) respectively. But there was a highly significant correlation between Pb in blood with Pb in follicular fluid of pregnant and non-pregnant group (r=0.94,P<0.01), (r=0.96,P<0.01) respectively. Also there was a highly significant correlation between Zn in Serum with Zn in FF (r=0.46,P<0.01) of non-pregnant. Conclusions: There was no significant difference between pregnant and non-pregnant groups undergoing ICSI cycle in Lead concentration on the day of oocytes retrieval in both blood and follicular fluid.There was no significant difference between pregnant and non-pregnant groups undergoing ICSI cycle in Zinc concentration on the day of oocytes retrieval in both serum and follicular fluid.

Keywords: Lead, Zn, ICSI, ART, FAAS.


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