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Abstract

NEW INSIGHTS INTO THE GUT MICROBIOME RESEARCH TO UNDERSTAND THE MICROBIAL DIVERSITY OF INDIAN AND WESTERN POPULATIONS WITH TYPE II DIABETES MELLITUS: A SHORT REVIEW

Ardhendu Bhusan Praharaj, Santosh Kumar Behera, Budheswar Dehury, Namita
Mahapatra* and Shantanu Kumar Kar

ABSTRACT

Gut flora comprises ecologically beneficial indigenous microbial
community that reside in the digestive tract of humans and inferred as
gut microbiota. The aggregation of the genomes of all these gut
microbiota is designated as gut meta-genome which play a pivotal role
in most of the gut-associated diseases. Diabetes is an autoimmune
disease whose incidence has rapidly surged through out all over the
globe over the last two decades. Accruing evidence suggests that
microbiota plays a key role in the biological mechanism of diabetes
and other diseases. Establishment of microbes in the colon begins at
birth, however, the succession and composition of the intestinal
microbial community depend upon several factors, however not
restricted to, the ageing, dietary, genetic variability, gender, geographic
region, and health status of an individual. Therefore, the inclusion of diverse study population
in the study of the gut microbiome is indispensable in case of Indian population which is
unique in terms of ethnicity, food habits and geographic location. This review is intended to
provide an association between gut microbiota and diabetes, which concisely explain the
significance of the intestinal microbes and its present status in between Indian and western
population. Further, this review has also explored the possible role and cause for the development of diabetes influenced by the gut microbiota. In conclusion, it can be suggested that Indian population could be the signatures required to promote the human health status by the clinicians.

Keywords: Diabetes Mellitus; Health Status; Life Style; Gastrointestinal Tract.


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