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Abstract

A REVIEW ON TOLPERISONE – CENTRALLY ACTING MUSCLE RELAXANT AND ITS ANALYTICAL METHODS

P. C. Indukala*, Praseetha K., Divya D. and Kathirvel S.

ABSTRACT

Method development is the process of proving that analytical method is acceptable for use to measure the concentration of active pharmaceutical ingredient in a specific compounded dosage form which must be validated to provide reliable data for regulatory submissions. Tolperisone is a piperidine derivative, centrally acting muscle relaxant, indicated for use in the treatment of pathologically increased tone of the cross striated muscle caused by neurological diseases(damage of pyramidal tract, multiple sclerosis, myelopathy, encephalomyelitis) and of spastic paralysis and other encephalopathy’s manifested with muscular dystonia. This article examines published analytical methods reported so far in the literature for the determination of Tolperisone in biological sample and pharmaceutical formulations. They include various techniques like spectrophotometry, High performance liquid chromatography, High performance thin layer chromatography and liquid chromatography-mass spectrometry.

Keywords: Tolperisone, analytical methods, muscle relaxant.


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