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Abstract

ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF NOVEL THIAZINE DERIVATIVES

Raja Sekhar K, Raj Kumar P, Srinivas Reddy K, Umasankar K, Gomathi 

ABSTRACT

In the present study analgesic and anti-inflammatory effects of 1,3- thiazine derivatives were investigated. Analgesic effect was evaluated by tail clip method and anti-inflammatory effect was evaluated by carrageenan induced rat paw edema method. Both the test compounds were found to be significant (P<0.01) at their ability to reduce the pain in mice. In anti-inflammatory activity the test compound 1 at 20 mg/kg dose was found to be significant (P<0.01) during third hour, while test compound 2 at 10 mg/kg and 20 mg/kg was found to be significant (P<0.01) during second hour in their ability to reduce the induced inflammation. These effects were compared with the effect of standard drug diclofenac sodium. From the results obtained, it is concluded that the synthetic 1,3- thiazine derivatives has good analgesic and anti-inflammatory activities and it showed a dose dependent activities.

Keywords: 1,3- thiazine derivatives, analgesic, anti-inflammatory, tail clip method.


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