WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

ANTI-ARTHRITIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF RANDIA DUMETORUM FRUITS IN FREUND’S COMPLETE ADJUVANT INDUCED ARTHRITIS

*Ritesh G. Patel1, Nimish L. Pathak1, Jaimik D. Rathod1, Dr.Nurudin P. Jivani1, Ravi U. Thaker2, Nayna M Bhatt1

1Department of Pharmacology, C.U.Shah College of Pharmacy and Research, Wadhwan, Gujarat, India
2Department of Pharmacology, Maliba Pharmacy College, Gopal Vidhyanagar, Bardoli, Surat. India

ABSTRACT

Randia dumetorum has multiple applications in traditional medicine because it exhibit Analgesic, Antifertility, Antibacterial, Antiinflammatory, Antiulcer, and Protective effects. However, no study on the anti-arthritic activity of Randia dumetorum has been reported in vivo. The present study was undertaken to determine efficacy of madecassoside (MA) against Freund’s complete adjuvant-induced arthritis (CFA) in female rat. Rheumatoid arthritis (RA) is a systemic autoimmune disease with chronic inflammation. It is characterized by hyperplasia of synovial cells in affected joints, which ultimately leads to the destruction of cartilage and bone. We investigated therapeutic efficacy of Randia dumetorum in treating Rheumatoid Arthritis (RA) using Freund’s complete adjuvant-induced arthritis (CFA) animal model. Arthritis was induced in female Wistar rats by intradermal injection of Freund’s complete adjuvant (CFA). CFA rats were treated daily with oral administration of different doses of Methanolic extract of Randia dumetorum(RD), beginning on the day after the onset of arthritis (day 21st, the therapeutic treatment) until day 28th. The results showed that treatment with Randia dumetorum markedly reduced paw swelling and arthritic index even in the established CFA. Radiologic and histopathologic changes in the arthritic joints were also significantly reduced in the Randia dumetorum -treated versus vehicle-treated rats. Moreover, Rheumatoid factor was significantly reduced in Randia dumetorum treated group in compared to disease control group. Hence, our studies demonstrate safety, and effectiveness of Randia dumetorum as an anti-arthritic agent, which makes Randia dumetorum a strong candidate for further research on rheumatoid arthritis (RA).

Keywords: Randia dumetorum, Rheumatoid arthritis, Freund’s complete adjuvant-induced arthritis.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More