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Abstract

VALIDATED VISIBLE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF DARUNAVIR IN BULK AND PHARMACEUTICAL DOSAGE FORM USING 1, 2 NAPHTHOQUINONE 4-SULPHONATE REAGENT

Mastanamma SK*, Sai Sirisha Vanukuri

ABSTRACT

The aim of the present study is to develop a new simple, precise Spectrophotometric method for estimation of Darunavir using 1, 2 Naphthoquinone 4-sulphonate in presence of an alkaline medium. Analysis was performed on Shimadzu UV-1800 UV-Visible spectrophotometer with spectral bandwidth of 1nm and using a pair of 10mm matched glass cells. The method is based on the formation of bright orange color complex formed by reaction of Naphthoquinone sulphonate with Darunavir. The nucleophilic substitution proceeds quantitatively in alkaline medium (0.01N NaOH) with an absorption maximum at 460nm. The calibration curve is linear over concentration range of 10-80μg/ml and the regression equation obtained was Y=0.014x+0.012 with regression coefficient R2=0.9997 and the Sandell’s sensitivity was found to be 0.09μg/ml. Accuracy and precision studies performed were found to be within limits.

Keywords: Darunavir (DRN), Spectrophotometric, 1, 2 Naphthoquinone 4-sulphonate (NQS), Pharmaceutical dosage form.


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