WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

A NOVEL APPROACH TO THE SYNTHESIS OF FLORFENICOL

Gaddam Prabhakar, Dasari Raju, Kadari Sudhakar & B.M.Choudary*

ABSTRACT

The article describes a convenient and ecofriendly synthetic route for the synthesis of florfenicol from readily available thiamphenicol 1 by using inexpensive and recyclable solid catalysts. The strategy is based on the preparation of cyclized alcoholic oxazolidin-2-one 3. This compound was protected with mesityl chloride in DCM and added Cu- HAP as a catalyst than followed by fluorinated with KF/PEG and added HAP as a catalyst to form fluorinated oxazolidin-2-one 5. This compound was opened up by reaction with sulfuric acid in dioxane and later the amino group was dichloroacetylated with methyldichloroacetate by copper hydrotalcite (Cu-HT-2) in DCM to obtained florfenicol 7 with good yield. All the synthesized compounds were established by their spectral and elemental analysis.

Keywords: Thiamphenicol, florfenicol, hydrotalcite, hydroxy apatite, Cu-hydrotalcite


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More