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Abstract

DESIGN AND DEVELOPMENT OF NOVEL ORILISTAT CHEWABLE TABLETS FOR THE TREATMENT OF OBESITY

Sathya Surya Prasad Ch.*, J. Vijaya Ratna, M. Mohan Varma

ABSTRACT

Today in the world at the pharmacy plays a vital and critical role in deciding the major studies of obesity and mortality fail to show that overall obesity leads to greater risk. Orlistat is a novel, nonsystemically acting anti-obesity agent used to treat obesity by preventing the absorption of fats from the human diet, thereby reducing caloric intake. The formulation tablet is a very complex process. Because of manufacturing defects due to low melting point sticky nature of the powder and stability of the API is poor. Now it’s challenging task to obtain in tablet dosage form a new pharmaceutical form with acceptable organoleptic properties and stable dosage form for batter therapeutic action. The chewable tablets were prepared by melt granulation technique by using different fatty acids. And FT-IR, Differential scanning calorimetry, X-Ray diffraction and scanning electron microscopy were performed to identify the physicochemical interaction between drug and carriers.

Keywords: Orlistat, chewable tablets, melt granulation method, fatty acids.


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