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Abstract

ESTIMATION OF QUETIAPINE FUMARATE IN TABLET DOSAGE FORM BY HPTLC METHOD

*Deepak Sahu1, A. C. Rana2

1Geetanjali Institute of Pharmacy, Udaipur, Rajasthan, India
2 Rayat Institute of Pharmacy, Ropar, Punjab, India

ABSTRACT

A simple, accurate, low cost and specific HPTLC method for estimation of quetiapine fumarate in tablet has been developed. It was performed on Silica gel G60 F254 aluminium foil using acetonitrile : chloroform in the ratio of 1:9 as mobile phase. The mobile phase having chamber was saturated for 20 minutes at room temperature. The Rf value of quetiapine fumarate was found to be 0.45. The plate was scanned and quantified at 242 nm. The calibration curve response was observed between 5-25 μg. The linear regression data showed good linear relationship of r = 0.999. The percent recovery was found to be 100.0 0.01.The developed method was validated for its accuracy and precision with suitable parameters.

Keywords: HPTLC, Quetiapine Fumarate, Rf value, Silica gel G60 F254.


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