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Abstract

QUALITY CONTROL PARAMETERS OF TWO DIFFERENT BRANDS OF CIPROFLOXACIN TABLETS IP AVAILABLE COMMERCIALLY AS PER INDIAN PHARMACOPOEIA

Barnali Gogoi, Himakshi Baishya*, Ripunjoy Bordoloi, Sanjib Kumar Sarma and Dr. Parthajyoti Gogoi

ABSTRACT

The aim of our present study is to evaluate the quality of two brands of Ciprofloxacin Tablets I.P which are available commercially whether they qualify the entire test mentioned in Indian Pharmacopoeia thereby suggesting their quality and efficacy for use among the general public. The study was exclusively experimental that used Indian Pharmacopoeia 2014 to check the in vitro quality of Ciprofloxacin Tablets I.P using different analytical techniques and procedure. All the two brands under the study were within the specification for weight variation test for tablet. The test for identification, assay and dissolution were carried out by High Performance Liquid Chromatography using U-HPLC System (Thermo- Dionex) equipped with an UV detector and stainless steel column (25cm × 4.6mm × 5μm) packed with octadecylsilane chemically bonded to porous silica. The dissolution study was carried out in Apparatus 1 of I.P. The dissolution medium used was 900ml of water, with the speed and time of apparatus set at 50rpm and 30 minutes respectively. The research work indicated that two different brands did not show much difference in their results and they were found to be within the acceptance limits. Hence the release pattern of the two brands of Ciprofloxacin tablets IP were found to be therapeutically effective.

Keywords: Ciprofloxacin, Indian Pharmacopoeia, Quality control.


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