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Abstract

DEVELOPMENT AND VALIDATION OF NEW SPECTROSCOPIC METHOD FOR THE ESTIMATION OF VALGANCYCLOVIR HCL IN BULK AND PHARMACEUTIC DOSAGE FORM

Sathish Kumar Konidala*, N Yamini Sai Silpa, K Samrajyam, O Tulasi Durga Deviand Dr R Srinivasan

ABSTRACT

The present study describes a simple, accurate, precise and cost effective UV-Spectrophotometric method for the estimation of Valgancyclovir Hcl, an anti-HIV drug, in bulk and pharmaceutical dosage form. The drug was first dissolved in 0.1N Hcl and final volume was made up with 0.1N Hcl. The λmax or the absorption maxima of the drug was found to be 250nm. A linear response was observed in the range of 4-20μg/ml with a regression coefficient of 0.999. The method was then validated for different parameters as per the ICH (International Conference for Harmonization) guidelines. This method can be used for the determination of Valgancyclovir Hcl in quality control of formulation without interference of the excipients.

Keywords: Valgancyclovir Hcl; UV-Spectrophotometric method; Validation; VALGAN tablets


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