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Abstract

FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF EXTENDED RELEASE MEBEVERINE HCL PELLETS

Amtun Noor*, P.R.Sathesh Babu, P. Aravind

ABSTRACT

The present study was aimed to formulate and evaluate extended release mebeverine hydrochloride pellets using fluidized bed coater. Mebeverine hydrochloride anti spasmodic drug being highly water soluble drug with a half life of 2 h suitable to develop extended action for treatment of irritable bowel syndrome. Nine formulations (M1-M9) of mebeverine hydrochloride pellets were prepared using a combination of two rate controlling polymers ethyl cellulose and HPMCP HP 55 and other standard excipients. The prepared pellets were subjected to micrometric properties and In vitro drug release studies. The optimized formulation M9 showed 87.91% drug release after 12 h. Scanning electron microscopy (SEM) studies revealed that the prepared pellets for mebeverine hydrochloride are spherical in shape. The release profile for optimized formulation M9 was comparable with that of marketed formulation (MEVA SR) for mebeverine hydrochloride. The mathematical model was built on the hypotheses that drug diffusion and drug dissolution in the release environment are the key phenomena affecting drug release kinetics and it was found to be followed first order and diffusion mechanism.

Keywords: Mebeverine hydrochloride; extended release; fluidized bed coater; irritable bowel syndrome.


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