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Abstract

VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF LOSARTAN AND ATORVASTATININ BULK PHARMACEUTICAL DOSAGE FORM

S.Shamili, M.M.Eswarudu*, M. Chinna Eswaraiah, L.Satish.

ABSTRACT

A simple, rapid, accurate and precise isocratic reversed-phase highperformanceliquid chromatographic method has been developed andvalidated for simultaneous estimation of Losartan and Atorvastatin intablet dosage forms. The chromatographic separation was carried outon Inertsil BDS C18 column (150 x 4.6 mm; 5μ) with mobile phaseconsisted of a mixture of Acetonitrile and water (0.1% Triethylamineis added) in the ratio of 50:50 delivered at a flow rate of 1.0 mL / minand UV detection was performed at 240 nm. The retention times were2.96 min and 3.87 min for Losartan and Atorvastatin respectively. Themethod was found to be linear in the range of 6.25-37.5μg/ml and 2.5-15μg/ml for Losartan potassium and Atorvastatin respectively. Thecoefficient of variance for both the drug was more than 0.999. Themethod was validated for linearity, accuracy, precision, specificity and sensitivity. Theproposed method was successfully used for quantitative analysis of Losartan and Atorvastatintablets. No interference from any component ofPharmaceutical dosage form was observed.Validation studies revealed that the method is specific, rapid, reliable and reproducible. Thehigh recovery and low relative standard deviation confirm the suitability of the proposedmethod for routine estimation of Losartan and Atorvastatin in bulk and tablet dosage form.

Keywords: Losartan, Atorvastatin, HPLC, Validation


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