WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

DESIGN AND EVALUATION OF POLYMERIC FILMS (HPMC) OF ENALAPRIL MALEATE FOR TRANSDERMAL USE

Hemantkumar Bhosale*, Pooja Bansude, Vishal Babar and Prajwala Khapale

ABSTRACT

Objective: The aim of the present investigation was to develop medicated and non-medicated transdermal films. Methods: Nonmedicated films were formulated with different ratios of polymers HPMC K4M and K100M glycerol as a plasticizer, whereas the medicated films were formulated of antihypertensive agent Enalapril maleate using same polymers and plasticizer. The possible drugpolymer interactions and compatibility were studied by FTIR and DSC studies. Results: Formulated transdermal films were formulated for various physicochemical characterization, in-vitro diffusion study, stability studies and in-vitro diffusion data was analyzed by using various kinetic models. The results of all physicochemical parameters were found to be within limits. The in-vitro diffusion study was performed using Franz diffusion cell and full thickness rat abdominal skin as a barrier. The in-vitro diffusion data revealed that JK4 formulation batch showed good permeation at the end of 10hrs. Conclusion: The physicochemical characterization and permeability studies indicate that the drug & polymers is suitable for Transdermal drug delivery.

Keywords: Transdermal films, HPMC K4M, HPMC K100M, glycerol, Enalapril maleate.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More