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Abstract

STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF LOPINAVIR AND RITONAVIR BY USING RP-HPLC

P. S. Raghu*

ABSTRACT

A simple, Accurate, precise method was developed for the simultaneous estimation of the Lopinavir and Ritonavir in Pharmaceutical dosage form. Chromatogram was run through Inertsil C18 (250mm 4.6mm, 5μ). Mobile phase containing Orthophosphoric acid buffer and Acetonitrile in the ratio of 44:6 was pumped through column at a flow rate of 1.0 ml/min. Temperature was maintained at 30°C. Optimized wavelength for Lopinavir and Ritonavir was 310nm. Retention time of Lopinavir and Ritonavir were found to be 2.214min and 3.163min. %RSD of the Lopinavir and Ritonavir were and found to be 0.6 and 0.3 respectively. %Recover was Obtained as 99.64% and 99.56% for Lopinavir and Ritonavir. LOD, LOQ values were obtained from regression equations of Lopinavir and Ritonavir were 0.20ppm, 0.61ppm and 0.08ppm, 0.24ppm respectively. Regression equation of Lopinavir y = 7745x+22310, and of Ritonavir is y = 11440x + 7469. Retention times were decreased and that run time was also decreased so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.

Keywords: Lopinavir, Ritonavir, RP-HPLC.


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