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Abstract

FORMULATION DESIGN AND OPTIMIZATION OF TASTE MASKED RAPID DISINTEGRATING TABLETS USING FREEZE DRYING METHOD

*Pravin K. Bhoyar1, Jagdish R. Baheti2, Prabhat A. Naranje3, Sharad Bhandarkar4, Rengini Muraleedharan4, Bhalchandra M. Deotale3

1Department Of Pharmaceutical Sciences, NIMS University, Jaipur, Rajasthan, India
2Shriman Suresh Dada Jain College of Pharmacy, Chandwad, Nasik, Maharashtra, India.
3Department of Pharmacy, Agnihotri College of Pharmacy, Wardha, Maharashtra, India.
4Department of Pharmacy, GIKIST College of pharmacy, Dist: Jabalpur, Madhya Pradesh, India

ABSTRACT

Trimetazidine HCl is used in angina pectoris and in ischaemia of neurosensoral tissue as in manieres disease. It will be much advantageous to present such drug in Rapid Disintegrating dosage form,as their administration is easier for the patient of angina attack. Bitter taste of the drug pose a main problem in patient compliance. Hence Eudragit EPO polymer was used for complexation with drug for overcoming taste problem . The Lyophilization method was used to form the drug polymer complex in a tablet. 1:3 ratio of the drug to polymer was effectively masked the bitter taste of drug. Hydolysed Gelatin were used in different ratios. 2% Gelatin forms the optimized tablet. FTIR studies were done to study the drug polymer interaction. Rapid Disintegrating Tablet was formulated in the blister packs using Freeze Drying Method. The tablets were evaluated for different evaluation parameters. The tablet batch TEG3 having 1:3 ratio of Drug:Eudragit EPO and 0.5% Hydrolysed Gelatin were selected as the optimized batches. The marketed formulation showed much longer disintegration time (2050.04) as compared to the presented formulations. Also the dissolution of marketed tablet is more (t90 around 13 min) as compared to the prepared tablet (t90 for TEP3 and TEG3 around 2.5 min).Thus prepared tablet is superior to marketed formulation in term of disintegration time and dissolution behavior. Accelerated stability studies for 3 months shows no appreciable change in tablet properties and dissolution characteristics.

Keywords: Trimetazidine Hcl, Taste masking, Eudragit EPO, Hydrolysed Gelatin, Rapid disintegrating tablets. Freeze Drying Method


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