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Abstract

FORMULATION, DEVELOPMENT AND IN VITRO EVALUATION OF IMMEDIATE RELEASE TABLET OF SITAGLIPTIN PHOSPHATE MONOHYDRATE.

Wale Kiran K*., Dr.Salunkhe K.S., Sayyed S.F., Dr. Chaudhari S.R., Snehal Hase.

ABSTRACT

The pivotal motif of the present research work is to develop immediate release tablet of sitagliptin phosphate monohydrate .the rate of dissolution and bioavailability of the sitagliptin phosphate monohydrate may be increased by using superdisintegrant in its immediate release tablets. This investigation is undertaken with an aim to develop pharmaceutically equivalent, stable, cost effective and quality improved formulation of sitagliptin phosphate monohydrate immediate release tablets. Wet granulation mehod was adapted to prepare the sitagliptin phosphate monohydrate immediate release tablets by using microcrystalline cellulose, lactose as diluents, crospovidone and sodium starch glycolate as superdisintegrant in different concentration (2-8%) to prepare (S1-S9) batches. tablet where prepared and evaluated forshardness, friability, weightvariation, contentuniformity, disintegrationtime and in-vitro drug release. Among all the formulations S1 to S9,formulation S8 disintegratedin 303 (sec.)in-vitro dissolution study of immediate release tablet was done in USP type II along with UV spectrophotometer gave cumulative % drug release of sitaglipti phosphate 99.98% at 45Min. From the study it was found that ,combination of high concentration crospovidone and low concentration of sodium starch glycolategood disintegration of sitagliptin phosphate tablet.

Keywords: sitagliptin phosphate monohydrate,SSG,PVP K-30,superdisintegrant


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