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Abstract

FORMULATION AND EVALUATION OF SOLID DISPERSION INCLUDE FAST DISSOLVING TABLETS OF TENOFOVIR DISOPROXIL FUMARATE

Sathya Surya Prasad Ch.*, J. Vijaya Ratna and M. Mohanvarma

ABSTRACT

The present study was to formulate solid dispersion include fast dissolving tablet of Tenofovir disoproxil fumarate to improve the aqueous solubility, dissolution rate. Solid dispersion of Tenofovir disoproxil fumarate was prepared with PVP K30, PEG 6000 and Soluplus in different drug: carrier ratio using physical mixing, solvent evaporation and kneading methods. FT-IR, Differential scanning calorimetry, X-Ray diffraction and scanning electron microscopy were performed to identify the physicochemical interaction between drug and carriers. The optimized solid dispersion (Drug: Soluplus 1:0.5 ratio in kneading method) were further used to prepare fast dissolving tablet by direct compression method using Superdisintegrants such as sodium starch glycolate, Cross carmallose sodium and crospovidone. The precompression parameter of powder blends suggested good flow ability and compressibility. The prepared tablets were evaluated for thickness, hardness, friability, weight variation, drug content, wetting time, in-vitro disintegration time and dissolution studies. The F6 formula shows highest release of 100.32% in 30 mins.

Keywords: Tenofovir disoproxil fumarate, Soluplus, sodium starch glycolate, direct compression method, fast dissolving tablet.


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