WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

PRELIMINARY ACUTE ORAL TOXICITY STUDY OF A NEWLY DEVELOPED HERBAL FORMULATION

Soumendra Darbar, Srimoyee Saha, Kausikisankar Pramanik and Atiskumar Chattopadhyay*

ABSTRACT

Toxicity is an expression of being poisonous, indicating the state of adverse effects led by the interaction between toxicants and cells. Acute toxicity studies are conducted to evaluate the effects of a single substances on animal model. The present study was designed to evaluate the acute oral toxicity study of herbal formulation (HF) according to OECD guidelines. In the present study, a single administration of the poly herbal extract at a dose of 2000 mg/kg, respectively, was given to the mice. Mice were observed for general appearance, behavior, body weight, adverse effects, mortality and necropsy up to 14 days post-treatment. In this study we could not find any mortalities during the experimental period. No changes in general appearance and mortality was observed. HF was found to be safe at dose of 2000mg/kg. In the conclusion these results demonstrate that the extract may not have any single dose toxicity.

Keywords: Acute toxicity; Herbal formulation; OECD guidelines; Necropsy.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More