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Abstract

DEVELOPMENT AND EVALUATION OF FAST DISSOLVING DRUG DELIVERY SYSTEM OF CILNIDIPINE

Mahaparale Paresh R.*, Thorat Vidhya P. and Gharge Vikram S.

ABSTRACT

Cilnidipine is poorly water soluble antihypertensive drug (BCS class
II). This study was conducted to increase solubility of drug. An attempt
was made to formulate fast dissolving tablet of Cilnidipine by solid
dispersion using melting method with Pluronic F-68. The API: carrier
was taken as 1:1, 1:2 and 1:3. Effect of several variables such as
concentration of superdisintegrant, drug: carrier ratios were studied.
Formulations were analyzed using Differential Scanning Calorimetry
(DSC), X-ray Diffraction (XRD) analysis, Fourier Transform-Infrared
spectroscopy (FT-IR) and in-vitro release studies followed by various
release kinetics. Drug release profile of pure drug was found 8%
within 15 minutes whereas tablet of Cilnidipine: Pluronic F-68(1:3) prepared by melting
method showed NLT 85% drug release in 15 minutes. Accelerated stability study was
carried out for period of 3 months, which indicated that tablets were unaffected at all the
exposed conditions.

Keywords: Fast Dissolving Tablet, Cilnidipine, Pluronic F-68, Melting method, Solid dispersion.


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