HEPATOPROTECTIVE ACTIVITY OF POLYHERBAL CURNA (CHURNA) ON ETHANOL MEDIATED PARACETAMOL INDUCED HEPATOTOXICITY IN RATS
Dr. Venu Sampath Kumar Golla*
ABSTRACT
Ethanol is widely used drink in beverages and paracetamol is widely
used drug throughout the world. Among the chronic alcoholics
Paracetmol induced hepatotoxicity is very severe. The present study
was extended to the combined model of ethanol and paracetamol
because in order to combat the severe hepatotoxicity produced by
combined effect of ethanol and paracetamol, no single plant derivative
or isolated active principle is sufficient. Hence a polyherbal
formulation of mixture of plant derived products is essential. The
polyherbal churna was prepared by mixing dried aqueous extract
powders of barks of Alstonia scholaris, Ficus bengalensis, Pongamia
pinnata and Ricinus communis in equal quantities. The prepared
churna was evaluated for hepatoprotective activity against the
paracetamol and ethanol induced hepatotoxicity. The hepatic damage in rats was evidenced
by elevated levels of SGPT, SGOT, ALP, Total protein and Total bilirubin. Ethanol mediated
Paracetmol induced hepatotoxicity was treated with churna showed significant activity by
comparing with silymarin and the results were further supported by histopathological studies.
Keywords: Hepatoprotective activity, polyherbal churna, Ethanol, Paracetmol, Silymarin.
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